Detection of ApoE gene polymorphism and serum Lp-PLA2 levels in patients with AD and sleep disorders
10.3969/j.issn.1006-5725.2017.23.028
- VernacularTitle:阿尔茨海默病伴睡眠障碍患者ApoE基因多态性及血清Lp-PLA2水平研究
- Author:
Kai CUI
1
;
Qin ZHANG
;
XiLing CHEN
Author Information
1. 450014,河南省郑州市郑州大学第二附属医院老年医学科
- Keywords:
Alzheimer′s disease;
sleep disorders;
ApoE gene;
Lp-PLA2
- From:
The Journal of Practical Medicine
2017;33(23):3959-3962
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between apolipoprotein E(ApoE)gene polymorphism and serum lipoprotein-associated phospholipid(Lp-PLA2)level in patients with AD and sleep disorders. Methods Sixty-two AD patients and 26 healthy controls were enrolled in this study.The polymorphisms of ApoE gene and lev-els of serum Lp-PLA2,IL-6 and other serological indexes were determined,respectively.The mini-mental state ex-amination(MMSE)and Pittsburgh sleep index scale(PSQI)were used to evaluate the cognition and sleep status of AD patients and healthy controls. Results(1)ApoE ε3/4 and ε2/4 genotype were significantly higher in AD patients with sleep disorders(AD-1 group)compared with the healthy controls(P<0 05),and ApoEε3/4 genotype was significantly higher in patients in AD-1 group compared with AD patients without sleep disorder(AD-2 group) (P < 0 05).(2)The ApoEε4 allele frequency in patients in AD-1 group was significantly higher than that in pa-tients in the control group(P<0 05).(3)Levels of serum Lp-PLA2 and IL-6 were significantly higher in AD pa-tients with the ApoEε4 allele compared with AD patients without the ApoEε4 allele(P < 0 05). Conclusion ApoE gene polymorphism has a certain relationship with levels of serum Lp-PLA2 and IL-6 in patients with AD and sleep disturbance,and it′s speculated that the effect of ApoE gene polymorphism on sleep disorder may be associat-ed with inflammatory reaction.
