Effects of different doses of propofol on cardiac pump function in morbidly obese patients
10.3969/j.issn.1006-5725.2017.24.031
- VernacularTitle:不同麻醉诱导剂量丙泊酚对病态肥胖患者心脏泵功能的影响
- Author:
Wuhao LIAO
1
;
Qirong ZOU
;
Deying JIANG
;
Jiayang LI
;
Jing LI
;
Xuemei PENG
Author Information
1. 暨南大学附属第一医院麻醉科
- Keywords:
propofol;
morbidly obese patients;
lean body weight;
total body weight
- From:
The Journal of Practical Medicine
2017;33(24):4145-4148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of different doses of propofol on cardiac pump function in morbidly obese patients. Methods Forty morbidly obese patients undergoing laparoscopic Roux-en-Y gastric by-pass were randomly divided into lean body weight(LBW)group and total body weight(TBW)group,with 20 cases in each group.In LBW group,patients were induced by propofol with a dose according to LBW(kg)×2.0 mg/kg but in TBW group,patients were induced by propofol depending on TBW of the patients.We monitored the changes of left ventricular ejection fraction(LVEF)and stroke volume(SV)in patients before anesthetic induction(T1)and at 1 min(T2)after propofol administration.At the same time,we monitored invasive arterial pressure,noninvasive arterial pressure,BIS,and SpO2.Results Compared with those measured at T1,LVEF and SV were decreased af-ter the induction of anesthesia in the 2 groups(P < 0.05);compared with LBW,TBW had greater influence on LVEF and SV after the induction of anesthesia(P<0.05);compared with those at T1,non invasive arterial blood pressure,invasive arterial blood pressure and mean arterial pressure decreased after theinduction of anesthesia (P<0.05);compared with LBW,TBW had no significant effect on noninvasive arterial blood pressure,invasive arterial blood pressure and mean arterial pressure after the induction of anesthesia(P < 0.05);BIS was less than 50 after the induction of anesthesia in 2 groups. Conclusion Propofol induction with a LBW-dependent dose has less influence on cardiac pump function in morbidly obese patients while ensuring the depth of anesthesia.
