Drug Factors in Unusual Change of International Normalized Ratio:A Study of 41 Cases of Elderly Patients Taking Warfain

VernacularTitle:41例服用华法林老年患者国际标准化比值异常变化的药物因素
Author: Xing XIAO ¹ ; Lun ZHOU ; Xiang GAO ; Cuntai ZHANG ; Ling TU
Author Information

1. 华中科技大学同济医学院附属同济医院综合医疗科
Keywords: Warfarin; International Normalized Ratio; Adverse drug reaction; Patient; elderly
From: Herald of Medicine 2018;37(1):107-109
CountryChina
Language:Chinese
Abstract: Objective To investigate the unusual drug-induced International Normalized Ratio(INR) change in elderly patients with warfarin treatment and its related mechanism. Methods A retrospective analysis was performed in 41 cases of elderly patients with unusual drug-induced INR change from 2011 to 2015 in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology. Results INR was increased unusually in 37 cases(90.2%) and was decreased unusually in 4 cases(9.8%).Intravenous drugs(80.5%) were prone to cause unusual INR change.Prostaglandin,antifungal drugs,antiarrhythmic drugs and lipid soluble vitamins were the commonly used drugs that induced adverse reaction,accounting for 26.8%,29.3%,29.3% and 9.8%,respectively. Conclusion Unusual drug-induced INR change is not rare in elderly patients with warfarin treatment during hospitalization.When other drugs are prescribed,INR should be measured more frequently and the dose of warfarin should be adjusted promptly.