Research progress of mesenchymal stem cells in the treatment of ALI

VernacularTitle:间充质干细胞治疗ALI的研究进展
Author: Huanping ZHOU ¹ ; Meiyun LIU ; Xin LYU
Author Information

1. 同济大学附属肺科医院麻醉科
Keywords: Acute lung injury; Acute respiratory distress syndrome; Mesenchymal stem cell; Therapy
From: Chinese Critical Care Medicine 2017;29(11):1039-1042
CountryChina
Language:Chinese
Abstract: Acute lung injury (ALI) is one of the most common clinical critical illnesses. Its severe stage is acute respiratory distress syndrome (ARDS), characterized by rapid onset and high mortality. There is no effective treatment. Based on many preclinical studies, mesenchymal stem cells (MSCs) have great potential as a therapeutic strategy for ALI, clinical trials are underway, and studies on the therapeutic effects of MSCs progressively deep into the molecular mechanism and continue to make new progress. However, the use of MSCs, their specific methods and risks, especially on the risk of iatrogenic tumor formation remains unresolved. In this paper, we reviewed the main problems in the application of MSCs in the treatment of ALI and the main problems in the application of MSCs in order to explore the feasibility and future direction of MSCs in the treatment of ALI.