Research progress of IL-8 in lung cancer
10.11958/20170724
- VernacularTitle:IL-8在肺癌中的研究进展
- Author:
jing Ya MIAO
1
;
Fang JIN
;
yu Peng XU
;
fei Xiao QIU
Author Information
1. 天津医科大学基础医学研究中心 300070
- Keywords:
lung neoplasms;
interleukin-8;
cancer stem cells;
prognosis;
review
- From:
Tianjin Medical Journal
2017;45(12):1333-1336
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide. Acquired drug resistance and metastasis are the main causes of treatment failure in lung cancer. Tumor microenvironment is a complex network for the survival and progression of tumor cells, in which inflammatory factors play a critical role in drug resistance and metastasis. Interleukin (IL)-8 is one of critical pro-inflammatory cytokines responsible for cell proliferation, invasion and metastasis, drug resistance and early recurrence in lung cancer. A serum based approach is advantageous for providing a real-time detection and evaluation of disease status in patients. In this review, we summarize the recent advances of IL-8 in predicting prognosis and radiation-induced lung toxicity (RILT), as well as increasing resistance and stem-like characteristics of lung cancer.
