Relationship between vitamin D level and lung diseases in premature infants
10.3969/j.issn.1000-3606.2017.12.010
- VernacularTitle:早产儿维生素D水平与肺部疾病的关系
- Author:
Qin ZHOU
1
;
Shanyu JIANG
;
Ting QIU
;
Yao WANG
;
Renqiang YU
Author Information
1. 南京医科大学附属无锡妇幼保健院新生儿科 江苏无锡 214002
- Keywords:
25(OH)D;
neonatal respiratory distress syndrome;
bronchopulmonary dysplasia;
premature infant
- From:
Journal of Clinical Pediatrics
2017;35(12):918-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between serum 25(OH)D level and lung diseases in premature infants. Methods The clinical data and the results of serum 25 (OH) D were collected in the preterm infants admitted to NICU from January 2015 to December 2016. According to the average level of serum 25 (OH) D, the premature infants were divided into low vitamin D group and high vitamin D group, and the differences of lung diseases between two groups were compared. Results A total of 115 premature infants were enrolled. The mean gestational age was (29.9±1.9) weeks, and the mean serum 25(OH)D level was (37.1±16.6) nmol/L. The rates of vitamin D deficiency [25(OH)D<50 nmol/L], vitamin D insufficient [25(OH)D 50-75 nmol/L] , and normal [25(OH)D≥75 nmol/L] were 71.3%, 17.4%, and 11.3%, respectively. The persistent positive airway pressure, oxygen therapy time, the incidences of neonatal respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD), and hospitalization days in the low vitamin D group were significantly higher than those in the high vitamin D group (P all<0.05). Conclusions Preterm infants with low vitamin D levels may increase the incidences of RDS and BPD, and prolong the length of hospitalization.
