The diagnostic value of ELISA detection of anti phospholipase A2 receptor antibody in idiopathic membranous nephropathy patients:a meta-analysis
10.3969/j.issn.1673-4130.2017.24.026
- VernacularTitle:ELISA检测抗PLA2R抗体对IMN诊断价值的meta分析
- Author:
Meili JIN
1
;
Lei REN
;
Fengyun MU
;
Yuwen WANG
;
Yanhong LIU
Author Information
1. 哈尔滨医科大学附属第二医院检验科
- Keywords:
anti phospholipase A2 recepter antibody;
ELISA;
idiopathic membranous nephropathy;
meta analysis
- From:
International Journal of Laboratory Medicine
2017;38(24):3429-3431,3439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of Enzymes linked immunosorbent assay(ELISA)detection of anti phospholipase A2 receptor antibody(anti-PLA2R)in idiopathic membranous nephropathy patients.Methods All articles published from January 2012 to April 2017 about ELISA test on anti phospholipase A2 recepeor antibody as a maker for IMN were collected, and the quality of the studies was evaluated by using the guidelines of the updated Quality Assessment of Diagnostic Accuracy Stud-ies(QUADAS-2)tool.According to the inclusion criteria and exclusion criteria,the research objects were selected and the data were extracted,and the analysis was carried out by Meta-Disc1.4 software.The results are summarized on the basis of sensitivity,speci-ficity,and summary receiver operating characteristic curve(ROC curve).Results Ten articles were selected according to inclusion criteria and 1517 cases were included in the study.The combined sensitivity was 0.68[95% CI(0.64,0.70)];the merge specificity was 0.92[95% CI(0.90,0.95)],and the subjects'working curve showed AUC 0.807 4.Conclusion The detection of anti-PLA2R by ELISA is effective in the diagnosis of idiopathic membranous nephropathy,which can be used as an effective supplement for the diagnosis of idiopathic membranous nephropathy.
