Effects of Clostridium Butyricum Combined with Antibiotics on Postoperative Inflammatory Factors and Gastrointestinal Function of Patients with Acute Appendicitis after Laparoscopic Surgery
10.6039/j.issn.1001-0408.2017.35.22
- VernacularTitle:酪酸梭菌联合抗菌药物对急性阑尾炎患者腹腔镜术后炎症因子及胃肠功能的影响
- Author:
Hui MA
1
;
Fan TANG
;
Jixue HOU
;
Xinchun ZHAO
Author Information
1. 石河子大学医学院第一附属医院胃肠乳腺外科
- Keywords:
Laparoscope;
Acute appendicitis;
Clostridium butyricum;
Antibiotics;
Inflammatory factor;
Gastrointestinal function
- From:
China Pharmacy
2017;28(35):4978-4980
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of clostridium butyricum combined with antibiotics on inflammatory factors and gastrointestinal function of patients with acute appendicitis after laparoscopic surgery. METHODS:A total of 102 patients with acute appendicitis undergoing laparoscopic surgery in our hospital during Jan. 2014-Jan. 2015 were divided into observation group and control group according to odd-even admission number,with 51 cases in each group. Control group was given Cefuroxime sodi-um for injection,Metronidazole injection and Cefixime dispersible tablets for anti-infective therapy after surgery. Observation group was additionally given Clostridium butyricum capsule 1260 mg,tid,for consecutive 3 d,on the basis of control group. The levels of serum inflammatory factors(TNF-α,IL-6),gastrin(GAS)and motilin(MTL)were compared between 2 groups before surgery and 3 d after surgery. The time of gastrointestinal function recovery(the time of bowel sounds,the time of first flatus,the time of postoperative first defecation)and the occurrence of compliance were recorded in 2 groups. RESULTS:Before surgery,there was no statistical significance in the levels of serum inflammatory and GAS,MTL factors between 2 groups (P>0.05). 3 d after sur-gery,the levels of TNF-α,IL-6 and CRP in 2 groups were decreased significantly,while the levels of GAS and MTL were in-creased significantly;above indexes of observation group were significantly better than those of control group,with statistical sig-nificance(P<0.05). The time of bowel sounds,the time of first flatus and the time of postoperative first defecation in observation group were significantly shorter than control group,with statistical significance(P<0.05). The incidence of complications in obser-vation group was 3.92％,which was significantly lower than 15.69％of control group(P<0.05). CONCLUSIONS:Clostridium bu-tyricum combined with antibiotics can effectively relieve inflammatory state of patients with acute appendicitis after laparoscopic sur-gery,promote gastrointestinal function recovery,and reduce the occurrence of complications.
