Literature Analysis of Sunitinib-induced ADR
10.6039/j.issn.1001-0408.2017.35.10
- VernacularTitle:舒尼替尼致不良反应的文献分析
- Author:
Binchi LIAO
1
;
Jing DU
Author Information
1. 国家食品药品监督管理总局高级研修学院
- Keywords:
Sunitinib;
ADR;
Literature analysis
- From:
China Pharmacy
2017;28(35):4932-4935
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for safe use of sunitinib in clinic. METHODS:Using"sunitinib""ADR"as re-trieval words,retrieved from PubMed,VIP,CNKI and Wanfang database during Jan. 2006-Mar. 2017,case reports and case series reports about sunitinib-induced ADR were collected and screened. In retrospective study,general information of patients,disease in-formation,involved organs or systems,clinical manifestations,ADR association evaluation and outcomes were analyzed statistical-ly. RESULTS:A total of 57 literatures were included,involving 66 cases,among which there were 15 new ADR. There were 34 male(51.52％)and 32 female(48.48％),with ratio of 1.06:1. Average age of patients was(63.4±10.5)years old. Sunitinib was mainly used for suprarenal epithelioma, accounting for 65.15％;followed by gastrointestinal stromal tumors, accounting for 21.21％. The incidence of ADR was the highest during 8-14 d(27.27％)and 22-28 d(22.73％)of medication. Organs/systems in-volved in ADR mostly were endocrine system(accounting for 25.76％). Main clinical manifestation was hypothyroidism,followed by diseases of skin and subcutaneous tissue(21.21％),diseases of the blood lymphatic system(16.67％)which mainly manifested as hand foot syndrome and thrombocytopenia (mainly being 4 degree bone marrow suppression). There were 9 cases of definite causal relationship and 57 cases of probable causal relationship. Fourteen cases of sunitinib-induced ADR were recovered after drug withdrawal(21.21％);27 cases were recovered after drug withdrawal and drug therapy(40.91％);17 cases had sequel after sur-gery,prolonging disease course and therapy (25.76％);there were 8 death cases (12.12％). CONCLUSIONS:Sunitinib-induced ADR involve various organs/systems,and there are fatal cases. In the process of clinical medication,we should strengthen the ob-servation and monitoring,timely ADR disposal to guarantee the safety of patients.
