Advances in the HIF-1α/p300 protein-protein interaction inhibitors
10.11665/j.issn.1000-5048.20170502
- VernacularTitle:靶向HIF-1α/p300蛋白-蛋白相互作用抑制剂的研究进展
- Author:
Xiaofei MO
1
;
Xiaoli XU
;
Yalou WANG
;
Qidong YOU
Author Information
1. 中国药科大学江苏省药物分子设计与成药性优化重点实验室
- Keywords:
HIF-1α;
p300;
protein-protein interaction;
antitumor;
progress
- From:
Journal of China Pharmaceutical University
2017;48(5):515-522
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia induced factor-1 α (HIF-1α) is a key regulation factor that helps tumor adapt itself to the hypoxia microenvironment.It regulates the expression of more than 100 target genes that control cell proliferation and survival,metabolism,angiogenesis,invasion and metastasis.HIF-1α/p300,a core complex that regulates downstream genes expression,is considered as a potential antitumor target.This review summarizes HIF-1 α signal pathway,the binding mode of HIF-1α/p300 protein-protein interaction and recent development on the HIF-1α/ p300 protein-protein interaction inhibitors,which provides reference to the design of this kind of inhibitors.
