Studies on in vitro Transdermal Permeability of Nifedipine Nanoemulsion Containing Different Permeation Enhancers
- VernacularTitle:含不同促透剂的硝苯地平纳米乳的体外透皮吸收特性研究
- Author:
Xianxi GUO
1
;
Wen HE
;
Wenying WU
;
Yunhe LÜ
Author Information
1. 武汉大学人民医院药学部 武汉430060
- Keywords:
Nifedipine nanoemulsion;
In vitro transdermal experiment;
Transdermal permeation enhancer;
N-Trimethyl chitosan
- From:
China Pharmacist
2017;20(12):2156-2159
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the in vitro transdermal permeability of nifedipine nanoemulsion ( NFNE) containing different per-meation enhancers to lay foundation for the development of transdermal nifedipine preparation. Methods: Franz diffusion cells were used to study the transdermal enhancement of NFNE with different transdermal enhancers ( Azone, oleic acid, TMC20, TMC40, TMC60). Results:The in vitro transdermal effect of NFNE was better than that of nifedipine (NF). The order of in vitro transdermal permeation enhancement was as follows: azone > oleic acid > TMC60 > TMC40 > TMC20, while the water-soluble transdermal permeation enhancers had faster effect. Conclusion:For NFNE, fat-soluble transdermal permeation enhancers have better effect.
