Curative efficacy of urinary kallidinogenase combined with aspirin in treatment of acute cerebral infarc-tion and its effects on serum markers
10.3969/j.issn.1006-5725.2017.21.029
- VernacularTitle:尤瑞克林联合阿司匹林对急性脑梗死患者血清学指标及临床疗效的影响
- Author:
Weiheng LU
1
;
Chenghong LUO
;
Chengju LIAO
;
Xiaomin FENG
Author Information
1. 523326,广东省东莞市第三人民医院神经内科
- Keywords:
acute cerebral infarction;
urinary kallidinogenase;
aspirin;
serological markers
- From:
The Journal of Practical Medicine
2017;33(21):3615-3618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of urinary Kallidinogenase combined with aspirin in treat-ment of acute cerebral infarction. Methods Eighty-six patients with acute cerebral infarction were randomly divid-ed into the observation group(n=43)and the control group(n=43).The observation group was treated with uri-nary Kallidinogenase combined with aspirin,while the control group was treated only with aspirin.Two weeks after the treatment,variables of hemorheology,serum Hcy,hs-CRP,VEGF,IL-6,Cys-C,neurological deficit(NI-HSS)and daily living ability(ADL)were compared between the two groups. Results After treatment,the serum Hcy,hs-CRP,VEGF,Cys-C,IL-6 levels,the NIHSS and ADL in the observation group were significantly better improved than those of the control group(P<0.05).The clinical efficacy in the observation group was significantly higher than that of the control group[95.35%(41/43)vs 74.42%(32/43)](P<0.05).Conclusion Urinary Kal-lidinogenase combined with aspirin is more effective in the treatment of acute cerebral infarction. The mechanism may be related to the early improvements of serum Hcy,hs-CRP,VEGF,Cys-C and IL-6 expression.
