Predictors of Refractory Ascites Development in Patients with Hepatitis B Virus-Related Cirrhosis Hospitalized to Control Ascitic Decompensation.
10.3349/ymj.2013.54.1.145
- Author:
Ju Hee SEO
1
;
Seung Up KIM
;
Jun Yong PARK
;
Do Young KIM
;
Kwang Hyub HAN
;
Chae Yoon CHON
;
Sang Hoon AHN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ahnsh@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Ascites;
chronic hepatitis B;
cirrhosis;
predictor;
refractory;
survival
- MeSH:
Adult;
Aged;
Ascites/complications/*diagnosis/mortality;
Female;
Hepatitis B, Chronic/complications/mortality/*therapy;
Hospitalization;
Humans;
Liver Cirrhosis/complications/mortality/*therapy;
Liver Transplantation;
Male;
Middle Aged;
Multivariate Analysis;
Potassium/blood;
Prognosis;
Retrospective Studies;
Treatment Outcome
- From:Yonsei Medical Journal
2013;54(1):145-153
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Refractory ascites (RA) is closely related to a high morbidity and mortality. In this study, we investigated predictors of RA development in patients with hepatitis B virus (HBV)-related cirrhosis who were hospitalized to control ascitic decompensation, and determined predictors for survival in patients who experienced RA. MATERIALS AND METHODS: We analyzed 199 consecutive patients with HBV-related cirrhosis who were hospitalized to control ascitic decompensation between January 1996 and December 2008. RESULTS: Multivariate analyses showed that only serum potassium at admission predicted RA development independently [p=0.013; hazard ratio (HR), 2.800; 95% confidence interval (CI), 1.166-6.722]. During the follow-up period, 16 (8.0%) patients experienced RA within 4.2 (range, 1.0-39.2) months after admission for controlling ascitic decompensation, and they survived a median of 8.7 (range, 3.9-51.3) months. Child-Pugh class and RA type were identified as independent prognostic factors affecting the survival in patients with RA (p=0.045; HR, 8.079; 95% CI, 1.231-67.984 and p=0.013; HR, 14.510; 95% CI, 1.771-118.874, respectively). CONCLUSION: Serum potassium was an independent predictor of RA development in patients with HBV-related cirrhosis who were hospitalized to control ascitic decompensation. After RA development, Child-Pugh class and RA type were independent predictors for survival.
