Diagnostic value of heart fatty acid binding protein and pregnancy associated plasma protein A in acute coronary syndrome
10.3969/j.issn.1673-4130.2017.20.003
- VernacularTitle:血浆H-FABP和PAPP-A在急性冠脉综合征中的诊断价值
- Author:
Zhaowei ZENG
1
;
Yanmin CHANG
Author Information
1. 天津市南开医院检验科
- Keywords:
heart fatty acid binding protein;
pregnancy associated plasma protein A;
acute coronary syndrome;
diagnosis
- From:
International Journal of Laboratory Medicine
2017;38(20):2808-2810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of heart fatty acid binding protein (H-FABP) and pregnancy associ-ated plasma protein A(PAPP-A) in acute coronary syndrome(ACS) .Methods A case-control study was conducted in 60 patients with ACS ,45 patients with stable angina pectoris (SAP) and50 patients without coronary heart diseases (control group) .All plasma samples were tested H-FABP and PAPP-A .Results Concentrations of H-FABP and PAPP-A were significantly different among the 3 groups(P<0 .01) .H-FABP and PAPP-A in ACS group were significant higher than those of SAP group and control group (P<0 .01) ,however there were no significant differences between SAP and control group (P>0 .05) .The sensitivity and specificity of H-FABP were 91 .7% and 78 .0% respectively analyzed by ROC curve .Similarly ,the sensitivity and specificity of PAPP-A were 48 .3% and 98 .0% respectively .The correlation of H-FABP and PAPP-A was high(r=0 .835 ,P<0 .01) according to the analysis by Pearson correlation analysis .Conclusion Concentrations of plasma H-FABP and PAPP-A had close relationship with ACS ,the sensitivity of H-FABP was much higher ,both of which could be the potential biomarkers and contributed to the diagnosis of exist-ence and progress of ACS .
