The influence of preoperative anxiety on popofol EC50 for no-movement during gastroscopy
10.3969/j.issn.1006-5725.2017.20.026
- VernacularTitle:术前焦虑对丙泊酚抑制胃镜检查术内脏性疼痛EC50的影响
- Author:
Hanwen CHEN
1
;
Shijian SHI
;
Zumin XING
;
Yanjing ZHANG
;
Jiyuan LI
;
Zhiqiang CHEN
;
Shile LIU
;
Cuiyun ZHOU
;
Yiwen ZHANG
Author Information
1. 南方医科大学顺德医院麻醉科
- Keywords:
propofol;
anxiety;
the median effective effect-concentration;
gastroscopy
- From:
The Journal of Practical Medicine
2017;33(20):3434-3436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the median(50%)effective effect-concentration(EC50)of propofol inducing loss of consciousness (LOC) varies. Methods 56 patients undergoing gastroscopy under general anaesthesia were enrolled on the study. Anaesthesia was conducted with a target-controlled infusion(TCI) of propofol. The initial target effect-site propofol concentration (Ceprop) was 5.00 μg/mL and was adjusted stepwise by 0.50μg/mL by an up-down sequential method to reach no-movement. Results Propofol EC50 to induce no-movement was higher in patients with anxiety than those without anxiety(6.46μg/mL vs. 5.75μg/mL,P<0.05). Conclusions During general anaesthesia ,patients with anxiety had a higher propofol EC50 for no-movement compared with those without anxiety. Differences in preoperative anxiety levels may reduce anaesthetic effects.
