Potential clinical value of detecting markers of bone metabolism in patients with ankylosing spondylitis
10.3969/j.issn.1000-484X.2017.10.021
- VernacularTitle:强直性脊柱炎患者检测骨代谢指标潜在的临床价值
- Author:
Ming Li TAN
1
;
Jing Xiao FENG
;
Jun An JIAO
;
Juan Juan CHEN
;
Yan Fu TAN
;
Qi Si HE
;
Yue Liu XU
;
Qing Yong JIANG
;
Heng LUO
Author Information
1. 南昌大学第二附属医院检验科
- Keywords:
Ankylosing spondylitis(AS);
Bone metabolism indexes;
C-reactive protein(CRP);
Human leukocyte antigen B27 (HLA-B27)
- From:
Chinese Journal of Immunology
2017;33(10):1543-1546,1562
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of bone metabolism indexes and human leukocyte antigen B27 (HLA-B27)in ankylosing spondylitis(AS)and analyze their diagnostic value. Methods:The subjects were 94 cases of AS patients,239 cases with other diseases and 80 healthy controls, and the results were retrospectively surveyed. Results:In the AS group, the concentration of the β-collagen specific sequence (β-CTX ) was higher ( P<0. 05 ) while the concentrations of osteocalcin ( OC ) , 25-hydroxyvitamin D[25-(OH)D] and parathyroid hormone(PTH)were lower than those in the control group. In the AS group,there was a positive correlation between the concentration of C-reactive protein(CRP)and β-CTX(P<0. 01),and the concentration of CRP was negatively correlated with the concentration of 25-(OH)D(P<0. 05). However,the concentrations of other bone metabolic indexes had no correlation with the concentration of CRP(P<0. 05). The positive rate of HLA-B27 in the AS group was significantly higher than that in other groups(P<0. 05),and HLA-B27 had highly sensitive and specific in the diagnosis of AS. In the AS group,the sensitivity of the concentration of 25-( OH) D was higher than β-CTX,while its specificity was lower than β-CTX. Conclusion:Bone metabolic indexes have great value in early screening and clinical diagnosis of AS,especially β-CTX and 25-( OH) D were more obvious.
