Preparation and Evaluation of Solid Lipid Nanoparticles Containing Ketoprofen
- VernacularTitle:酮洛芬固体脂质纳米粒的制备与评价
- Author:
Xiaoning WANG
1
;
Guoping LUO
;
Weize LI
;
Mengru YAN
;
Jinxiu LI
Author Information
1. 西安医学院药学院 西安710021
- Keywords:
Ketoprofen;
Solid lipid nanoparticles;
Encapsulation efficiency;
In-vitro release
- From:
China Pharmacist
2017;20(10):1705-1709
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare ketoprofen-loaded solid lipid nanoparticles ( SLN) and evaluate the properties. Methods: The formula was optimized by orthogonal experiments with the encapsulation efficiency as the index. The optimal preparation was investiga-ted by the morphology, particle size, zeta potential and drug forms. The release property was characterized by a dialysis method and the release process was fitted. Results: The best formula was as follows: poloxamer 0. 1g, Tween-800. 2g, lecithin 0. 15g, glycerol monostearate 0. 05g and ketoprofen 50mg. The particles were spherical in shape with the encapsulation efficiency of 61. 95%, the par-ticle size was 151. 7 nm and the zeta potential was-30. 2 mV. The result of DSC indicated the drug dispersed in the lipid matrix was a-morphous and molecular state. The in-vitro release curve showed the release was rapid at the early stage and then slowed down with the accumulated amount up to (85. 11 ± 7. 62)% in 12h. The drug was released slowly from SLN with the matrix erosion. The release pro-file fitted well with a Higuchi equation. Conclusion: The solid lipid nanoparticles containing ketoprofen exhibit good quality and the preparation method is simple and feasible, therefore, it is valuable to be further studied.
