The Effects of (66)Ho-Loaded Radioactive Stent in a Porcine Model.
10.4070/kcj.2002.32.6.479
- Author:
Dong Chea LEE
1
;
Myung Ho JEONG
;
Kun Hyung KIM
;
Han Sle LEE
;
Hee Seung BOM
;
Young Don HONG
;
Sun Ju CHOI
;
Kyung Bae PARK
;
Eun Hee KIM
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center, Chonnam National University Hospital, Gwangju, Korea.
- Publication Type:Original Article
- Keywords:
Coronary restenosis;
Stents;
Thrombosis;
Radioisotopes
- MeSH:
Constriction, Pathologic;
Coronary Restenosis;
Coronary Vessels;
Hyperplasia;
Inflammation;
Percutaneous Coronary Intervention;
Phenobarbital;
Polyurethanes;
Radioisotopes;
Stents*;
Thrombosis
- From:Korean Circulation Journal
2002;32(6):479-484
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Vascular brachytherpy known to be an effective method in the prevention of restenosis following percutaneous coronary intervention (PCI). In this study we observed the effects of a radioisotope-loaded stent in a porcine model. MATERIALS AND METHODS: Holmium-166 ((166)Ho) was loaded onto the stent surface using impregnated polyurethane, and placed the stents into 7 porcine coronary arteries. Four weeks after stent overdilation injury, histopathological examination was performed. RESULTS: The absorbed dose of (166)Ho to the coronary artery, from the 158.5+/-140.9 microCi (166)Ho stent, was about 141 Gy at a depth of 0.5 mm, which was calculated by Monte Carlo EGS 4 Code. The mean external, and internal elastic lamina areas, the luminal and neointimal areas and the histopathological area stenosis in the 7 porcine coronary arteries were 7.6+/-2.8 mm2, 4.7+/-1.6 mm2, 2.4+/-1.4 mm2, 2.3+/-1.6 mm2 and 49.4+/-24.9%, respectively. The histopathological findings revealed remarkable inflammatory reactions and thrombosis in two of the porcine coronary arteries. CONCLUSION: (166)Ho radioactive loaded stents, using impregnated polyurethane, may inhibit neointimal hyperplasia, but the problems of stent thrombosis and inflammation should be solved.
