Activation of Nuclear Factor-kappaB in the Atherosclerotic Human Coronary Artery.
- Author:
Eun Kyung SHIN
1
;
Min Kyung KIM
;
Jun Suk AHN
;
Seung Oh KIM
;
Jae Hak LEE
;
Jeong Hyun PARK
;
Jang Hee HAHN
;
Chun Kyu CHO
;
Seung Muk CHO
;
Tae Jeong KWON
;
Dae Joong KIM
Author Information
1. Department of Anantomy, College of Medicine, Kangwon National University, Korea. camackim@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary artery;
Atherosclerosis;
NF-kappaB
- MeSH:
American Heart Association;
Atherosclerosis;
Classification;
Coronary Vessels*;
Humans*;
Macrophages;
Myocytes, Smooth Muscle;
NF-kappa B;
Paraffin
- From:Korean Journal of Anatomy
2006;39(2):111-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paraffin sections of atherosclerotic vessels were classified into initial lesion, preatheroma and complicated severe lesion by classification method from American Heart Association. Activation of NF-kappaB was hardly detectable in the initial atherosclerotic lesion. In the preatheroma, activated NF-kappaB was enhanced in the neointimal smooth muscle cells and macrophages in the lipid core. In contrast, activated NF-kappaB increased markedly in the neointimal and medial smooth muscle cells in the severe atherosclerotic vessel wall. However, in the severe lesion, NF-kappaB activation was diminished in the macrophages of lipid core. Our findings show that NF-kappaB was activated in the smooth muscle cells with the progression of atherosclerosis in the human coronary artery.
