Association between oxidative stress and blood pressure in Korean subclinical hypertensive patients.
10.4163/kjn.2013.46.2.126
- Author:
Jeong Hwa HAN
1
;
Hye Jin LEE
;
Hee Jeong CHOI
;
Kyung Eun YUN
;
Myung Hee KANG
Author Information
1. Department of Food & Nutrition, College of Life Science and Nano Technology, Hannam University, Daejeon 305-811, Korea. mhkang@hnu.kr
- Publication Type:Original Article
- Keywords:
blood pressure;
oxidative stress;
antioxidative status;
DNA damage;
lipid profiles
- MeSH:
alpha-Tocopherol;
beta Carotene;
Blood Pressure;
Catalase;
Cholesterol;
DNA Damage;
Erythrocytes;
Glutathione;
Glutathione Peroxidase;
Humans;
Hypertension;
Korea;
Lipid Peroxidation;
Logistic Models;
Lymphocytes;
Oxidative Stress;
Plasma;
Surveys and Questionnaires;
Superoxide Dismutase;
Vitamins
- From:The Korean Journal of Nutrition
2013;46(2):126-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was conducted in order to investigate the association between hypertension and oxidative stress-related parameters and to evaluate these parameters in subclinical hypertensive patients and normotensive subjects living in Korea. We attempted to determine whether oxidative stress-related parameters would differ between two groups of 227 newly-diagnosed, untreated (systolic blood pressure (BP) > or = 130 mmHg and diastolic BP > or = 85 mmHg) and 130 normotensive subjects (systolic BP < 120 mmHg and diastolic BP < 80 mmHg). General characteristics of the subjects were collected using a simple questionnaire. From subjects' blood, degree of DNA damage in lymphocytes, the activities of erythrocyte superoxide dismutase, catalase, and glutathione peroxidase, level of plasma total radical-trapping antioxidant potential (TRAP), glutathione, and anti-oxidative vitamins, as well as plasma lipid profiles and conjugated diene (CD) were analyzed. Evaluation of the associations of oxidative stress-related parameters with blood pressure of the subjects was performed using Pearson partial correlation and multivariate logistic regression analysis after adjusting for confounding factors. Several oxidative stress-related parameters were higher in subclinical hypertensive patients than in normotensive subjects. Plasma levels of alpha-tocopherol, beta-carotene, TRAP, and activity of GSH-px were significantly lower in subclinical hypertensive patients than in normotensive subjects. Increased levels of DNA damage, lipid peroxidation, triglyceride, total cholesterol, and LDL-cholesterol were observed in subclinical hypertensive patients. These results confirm an association between blood pressure and oxidative stress-related parameters and suggest that the pathogenic role of oxidative stress in hypertension might be significant.
