Oral cancer resection and reconstruction without blood transfusion by using recombinant human erythropoietin.
10.5125/jkaoms.2011.37.1.9
- Author:
Chul Hwan KIM
1
;
Chung Hyun LEE
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Choenan, Korea. kimchoms@dankook.ac.kr
- Publication Type:Case Report
- Keywords:
Recombinant erythropoietin;
Blood transfusion;
Mouth neoplasms
- MeSH:
Anesthesia, General;
Blood Transfusion;
Carcinoma, Squamous Cell;
Disulfiram;
Emergencies;
Erythropoietin;
Female;
Forearm;
Gingiva;
Humans;
Iron;
Molar;
Mouth Neoplasms;
Neck Dissection;
Skin;
Surgery, Oral;
Transplants;
Ulcer
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2011;37(1):9-14
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recently, the population of patients who refuse transfusion has increased for both religious and non-religious reasons, even in life threatening emergency situations. Their refusal has highlighted the need to develop nonblood transfusion surgery techniques to decrease the risk from blood transfusions. A 57-year woman with an ulcerative lesion on the gingiva of the right upper molar area visited the department of oral and maxillofacial surgery in Dankook University Dental Hospital. After a preliminary evaluation, the patient was diagnosed with squamous cell carcinoma. As she refused blood transfusion during surgery for religious reasons, surgery was planned using recombinant human erythropoietin (rHuEPO) without a blood transfusion. The patient underwent a partial maxillectomy, supraomohyoid neck dissection, free radial forearm flap and split thickness skin graft under general anesthesia. rHuEPO and iron were used before and after surgery. The hemoglobin/hematocrit (Hb/Hct) level, iron (Fe) and total iron-binding capacity (TIBC) were assessed. The patient recovered completely without any blood transfusions. rHuEPO is a viable alternative for patients with religious objections to receiving blood transfusions.
