Detection of Integrons and Staphylococcal Cassette Chromosome mec Types in Clinical Methicillin-resistant Coagulase Negative Staphylococci Strains.
10.24171/j.phrp.2017.8.1.06
- Author:
Fahimeh HAJIAHMADI
1
;
Elham Salimi GHALE
;
Mohammad Yousef ALIKHANI
;
Alireza MORDADI
;
Mohammad Reza ARABESTANI
Author Information
1. Department of Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran. mohammad.arabestani@gmail.com
- Publication Type:Original Article
- Keywords:
coagulase-negative staphylococci;
integrons;
staphylococcal cassette chromosome mec
- MeSH:
Coagulase*;
Drug Resistance, Microbial;
Integrons*;
Interspersed Repetitive Sequences;
Iran;
Methicillin Resistance*
- From:
Osong Public Health and Research Perspectives
2017;8(1):47-53
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Integrons are thought to play an important role in the spread of antibiotic resistance. This study investigates class 1 and 2 integron-positive methicillin-resistant coagulase-negative staphylococci strains isolated in Iran and characterizes their patterns of antimicrobial resistance. METHODS: Hundred clinical isolates of coagulase-negative staphylococci were characterized for integron content and staphylococcal cassette chromosome mec (SCCmec) type. RESULTS: Sixteen isolates carried class 1 (intI1) integrons and four isolates carried class 2 (intI2) integrons. One resistance gene array was identified among the class 1 integrons (aadA1 cassette). The distribution of SCCmec types in 50 methicillin-resistant coagulase-negative staphylococci strains showed that SCCmec types III and V dominated among the tested strains. CONCLUSION: This is the first report of methicillin-resistant coagulase-negative staphylococci strains that carry two mobile genetic elements, including class 1 and 2 integrons and SCCmec, in Iran.
