Therapeutic Effect of Zinc and Lipoprostaglandin E1 for Idiopathic Sudden Hearing Loss.
10.3342/kjorl-hns.2015.58.5.318
- Author:
Ho Yun LEE
1
;
Ji Chan KIM
;
Dong Sik CHANG
;
Myoung Su CHOI
;
Chin Saeng CHO
;
Ah Young KIM
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Eulji University, Daejeon, Korea. kimayong@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
Profound;
Prostaglandin;
Steroid;
Sudden hearing loss
- MeSH:
Dizziness;
Hearing;
Hearing Loss;
Hearing Loss, Sudden*;
Humans;
Linear Models;
Retrospective Studies;
Zinc*
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2015;58(5):318-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: We aimed to analyze the therapeutic effect of zinc, lipoprostaglandin E1 in addition to systemic steroid therapy on hearing improvement for the treatment of idiopathic sudden hearing loss. SUBJECTS AND METHOD: Retrospective medical chart reviews of 500 patients who had been diagnosed with unilateral idiopathic sudden hearing loss between May 2006 and April 2014 were performed. Then, we conducted a multiple linear regression analysis using the data of individual patients. RESULTS: Better hearing gain was associated with low tone hearing loss (p<0.001), better initial contralateral hearing (p<0.001), and the absence of dizziness (p=0.015). Patients who underwent intratympanic steroid treatment as salvage treatment showed a lower hearing gain (p<0.001). Zinc supplementation was effective for the treatment of patients with mild hearing loss (p<0.001). On the contrary, significant improvements in hearing gain were found in patients with profound hearing loss who were treated with an additional lipoprostaglandin E1 (p<0.001). CONCLUSION: An additional use of zinc and lipoprostaglandin E1 may enhance hearing improvement for the treatment of idiopathic sudden hearing loss.
