Experimental study on cardiac pathological change in rats fed with corn and bean puree of Keshan disease area
10.3760/cma.j.issn.1000-4955.2009.03.015
- VernacularTitle:克山病病区玉米及酱块对大鼠心肌损伤的实验研究
- Author:
Li-jun, ZHANG
;
Ming-fa, LIU
;
Jie, CHEN
;
Shao-chen, LI
;
Jun-rui, PEI
;
Ling-wang, ZHOU
;
Yang, LIU
;
Tong, WANG
;
Wei-han, YU
;
Bao-xiong, TI
- Publication Type:Journal Article
- Keywords:
Keshan disease;
Glutathione peroxidase;
Myacardium;
Corn
- From:Chinese Journal of Endemiology
2009;28(3):291-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the myocardial damage in rats fed with corn from Keshan disease area added with bean puree. Methods Male Wistar rats were randomly divided into 3 groups according to their body weights, and fed with corn, corn from Keshan disease area added with bean puree, corn from non-endemic area. The GSH-Px activity of vena cardalis blood was examined in 1 and 3 months, rats were sacrificed after being fed for 6 months to examine the heart changes with HE stain. Results The three groups of GSH-Px activity were different in 1 and 3 months respectively(F=23.60,72.46, all P<0.01); GSH-Px activity was (181.58±22.15), (44.76±28.59)U/L in rats fed with corn, was (195.03±17.66), (30.38±3.35)U/L in those fed with corn added with bean puree from Keshan disease area, lower than the group fed with corn of non-endemic area[(340.90±95.42), (125.17±13.64)U/L, all P < 0.01]. But the difference of GSH-Px activity between simple corn group and corn adding bean puree groups of Keshan disease area was not obvious(P>0.05). Myocardial damage incidence of the three groups was 3/9,1/9,2/7. Difference among three groups did not have statistical significance(χ2=1.33, P> 0.05). Conclusions Only corn from Keshan disease area may induce myocardial damage pathology change. Adding bean puree into corn does not increase damage.
