Influence of Vascular Endothelial Growth Factor on Expression of Pulmonary Surfactant Protein B in Premature Rats
- VernacularTitle:血管内皮生长因子对早产鼠肺泡表面活性物质结合蛋白B的影响
- Author:
tao, LI
;
yu, XIAO
;
hong-wei, WANG
;
gen-rong, MAI
;
shao-yong, XU
;
ji-jian, XIE
;
dong-sheng, LI
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
alveolar epithelial cell Ⅱ;
pulmonary surfactant protein B
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of vascular endothelial growth factor(VEGF) on development of alveolar epithelial cell Ⅱ (AECⅡ) and expression of pulmonary surfactant protein B(SP-B) in premature rats.Methods Wistar rats at 19 days gestation were paunched to get embryo and primary AECⅡculture.The rats were divided into 4 groups ,VEGF-165 group,Dexamethasone group,VEGF and Dexamethason group,control group. AECⅡ and SP-B expression were measured by immunology histochemistry.Results SP-B had positive expression in VEGF group, Dexamethason group, VEGF and Dexamethason group. SP-B had negative expression in control group.Conclusion VEGF-165 can increase SP-B positive expression and secret of AECⅡ.VEGF promotes lung maturity.
