Molecular Epidemiology and Sequencing of the G-L Intergenic Region of Rabies Viruses Isolated in China
- Author:
Sheng-Li, MENG
;
Ge-Lin, XU
;
Jia-Xin, YAN
;
Ping-Gang, MING
;
Jie, WU
;
Xiao-Ming, YANG
;
He-Tian, MING
;
Feng-Cai, ZHU
;
Dun-Jin, ZHOU
;
QI-You, XIAO
;
Guan-Mu, DONG
- Publication Type:Journal Article
- Keywords:
Rabies virus;
Molecular Epidemiology;
G-L intergenic region;
China
- From:Virologica Sinica
2007;22(1):26-33
- CountryChina
- Language:Chinese
-
Abstract:
A group of 25 rabies viruses (RABVs),recovered from 24 dogs and one human case,were collected from various areas in China between 2004 and 2006.Genetic and phylogenetic analyses of the G-L intergenic region were carried out in 25 street RABV isolates and CTN vaccine strains of 7 generations.The study was based on the comparison of a 519 bp nucleotide sequence,encompassing the G-L intergenic region.The nucleotide sequence homologies of Chinese street strains were from 95.5% to 100%.The phylogenetic analysis showed that all Chinese isolates clearly supported the placement of all Chinese viruses in Lyssavirus genotype 1 and they were distributed according to their geographical origins.All of the Chinese strains were closely related but they could still be divided into two groups:group of street strains and group of CTN strains.This study presents details about the molecular epidemiology of rabies viruses based on the sequences of the G-L Intergenic region.
