Pharmacokinetic study on lovastatin sustained-release tablet and sustained-release capsule in Beagal dogs.
- Author:
Lin, FU
;
Zongshun, DAI
;
Shuxian, HOU
;
Yuanshen, WAN
- Publication Type:Journal Article
- MeSH:
Anticholesteremic Agents/*pharmacokinetics;
Capsules;
Delayed-Action Preparations;
Lovastatin/*pharmacokinetics;
Tablets
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(2):116-9
- CountryChina
- Language:English
-
Abstract:
This study pharmacokinetically examined the lovastatin sustained-release tablet and sustained-release capsule in Beagle dogs. An reversed-phase HPLC method was established for the determination of lovastatin in Beagle dog plasma. Pharmacokinetic findings were compared among three preparation(lovastatin sustained-release tablet, Tp; sustained-release capsule, TJ and conventional capsule). Our results showed that the pharmacokinetic parameters in 6 dogs after single-dose oral administration of three perparations were calculated. Tmax, Cmax and MRT revealed significant difference (P<0.05). Relative bioavailability was 111.5 +/- 16.9% (Tp) and 110.4% +/- 9.6% (Tj). The pharmacokinetic parameters in the 6 dogs after multiple-dose oral administration of three perparations, Tmax, Cmax MRT and DF had significant difference (P < 0.05); Cav, Cmin and AUC0-24 h displayed no significant difference (P>0.05). It is concluded that the lovastatin sustained-release tablet and sustained-release capsule are able to maintain a sustained-release for 24 h.
