Association of coronary flow reserve by dipyridamole technetium-99m sestamibi single photon emission computed tomography with perfusion findings and risk factors for coronary artery disease.
- Author:
Tumapon Deverly D.
;
Obaldo Jerry M.
- Publication Type:Clinical Trial
- Keywords: Coronary Flow Reserve
- MeSH: Human; Male; Female; Arteries; Coronary Artery Disease; Dipyridamole; Hypertrophy, Left Ventricular; Risk Factors; Technetium Tc 99m Sestamibi; Tomography, Emission-computed, Single-photon
- From: The Philippine Journal of Nuclear Medicine 2015;10(1):8-14
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND: Blunting of coronary flow reserve (CFR) may precede overt ischemia. The study aimed to correlate CFR with perfusion findings and risk factors for coronary artery disease (CAD).
METHODS: Fifty-four consecutive patients underwent dipyridamole-rest technetium-99m sestamibi single photon emission computed tomography (SPECT) on two separate days. CFR was computed as the quotient of myocardial blood flow (MBF= global tissue perfusion divided by arterial input function) at stress and at rest.
RESULTS: CFR was significantly lower in patients with abnormal perfusion vs normals (p=0.005). Reduced CFR was noted in 83% of patients with normal SPECT. Lower CFR was seen in hypertensive patients with left ventricular hypertrophy (LVH) compared to those without LVH (p=0.029); likewise in DM vs no DM (p=0.121). Independent predictors of reduced CFR were age and extent of ischemia.
CONCLUSION: Abnormal perfusion is associated with reduced CFR. In those with normal perfusion, there is a high prevalence of reduced CFR, which may be attributed to the presence of risk factors for CAD and LVH.