Rosai-Dorfman disease presenting as recurrent nasal polyposis
- Author:
Neil Louis L. Apale
1
;
Joel A. Romualdez
1
;
Rodolfo E. Rivera
1
Author Information
- Publication Type:Case Reports
- MeSH: Human; Adult; Histiocytosis, Sinus; Emperipolesis
- From: Philippine Journal of Otolaryngology Head and Neck Surgery 2014;29(2):22-24
- CountryPhilippines
- Language:English
- Abstract: OBJECTIVES: To present a case of Rosai-Dorfman disease in an individual with a 14-year history of recurrent nasal polyposis and discuss its clinical presentation, physical examination, radiologic findings, histopathologic characteristics and available treatment. METHODS: Design: Case Report Setting: Tertiary Government Hospital Patient: One RESULTS: A 26-year-old Filipino diagnosed and repeatedly treated medically and surgically for recurrent nasal polyposis underwent repeat endoscopic sinus surgery. A histopathologic impression of Rosai-Dorfman disease was confirmed by positive S-100 and CD1a negative immunochemistry in conjunction with the morphologic findings. CONCLUSION: Rosai-Dorfman disease is a rare entity which should be considered when dealing with recurrent nasal polyposis that is intractable to initial medical and surgical therapies. Histopathologic findings of emperipolesis and immunohistochemical S-100 stains play a key role in the diagnosis but there is yet no definite treatment for this disease.
- Full text:66 pjohns.pdf
