Pharmacogenomics screening of HLA-B*1502 in epilepsy patients: How we do it in the UKM Medical Centre, Malaysia
- Author:
Sue-Mian Then
;
Zam Zureena Mohd Rani
;
Azman Ali Raymond
;
Rahman Jamal
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(s1):27-29
- CountryMalaysia
- Language:English
-
Abstract:
Previous studies have shown that carbamazepine-induced Stevens-Johnson syndrome (SJS) and
toxic epidermal necrolysis (TEN) patients is associated with the HLA-B*1502 allele. Screening for
HLA-B*1502 before using carbamazepine can prevent SJS/TEN particularly in populations with high
frequency of the allele. The objective of this paper was to describe how the UKM Medical Centre,
Malaysia was able to set up a cost effective screening of HLA-B*1502 for patients taking carbamazepine.
The cost of in-house HLA-B⁄1502 screening was less than those commercially available, and was
sensitive and specifi c.
- Full text:P020150706597085482260.pdf
