Comparative study on clinicopathologic characteristics and prognosis between triple-negatlve and HER-2-overex pressed breast cancer
10.3760/cma.j.issn.1674-6090.2011.03.006
- VernacularTitle:三阴性乳腺癌与HER-2过表达乳腺癌患者的临床病理特征及预后比较
- Author:
Jundong WU
;
Wenhe HUANG
;
Ming CHEN
;
Xiaolong WEI
;
Changchun MA
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Triple negative breast cancer;
HER-2/neu;
Prognosis
- From:
Journal of Endocrine Surgery
2011;05(3):161-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare clinicopathological characteristics and prognosis between triple-negative and HER-2-overexpressed breast cancer patients.Methods From Jan.1997 to Jan.2007,data of 725 cases of primary breast cancer patients undergoing surgical treatment were analyzed.The patients were classified into triple-negative and HER-2-overexpressed phenotypes based on immunohistochemistry results.The clinicopathological characteristics and survival of the 2 groups were compared.Results Of the 725 cases,triple-negative and HER-2-overexpressed phenotypes accounted for 12.29%and 24.96%respectively.Compared with HER-2-overexpressed group,the triple-negative group had significantly higher proportion of familial history of malignancy (18.4% vs 5.5%,P=0.001)and higher proportion of patients'histological grade reaching grade 3(54.0% vs 42.0%,P=0.01).There were more lymph node metastasis in triple-negative group than that in HER-2-overexpression group(N1+N2+N3:74.7%vs 64.6%,P=0.045).The recurrence and metastasis rate within 2 years and brain metastasis rate in triple-negative group were higher than those in HER-2-overexpressed group (25.3%,8.0%vs 8.8%,2.2%,respectively,P<0.05).The 5-year disease-free survival rate in triple-negative group was significantly lower than that in HER-2-overexpressed group(55.6%vs 69.8%,P=0.041).There was no statistical difference between the 2 groups in terms of age,menopausal status,tumor size,pathological stage,surgcal procedure,pathological type,adjuvant radio-chemotherapy,the proportion of metastasis to liver,lung and bone as well as overall survival rate(P>0.05).Conclusion Compared to HER-2-overexpressed group,patients with triple-negative breast cancer show higher rate of familial history of malignancy,and they are associated with higher histological grade and poor prognosis.
