Loss of fragile histidine triad gene expression in papillary thyroid carcinoma
10.3760/cma.j.issn.1674-6090.2014.01.010
- VernacularTitle:FHIT基因表达缺失在甲状腺乳头状癌中的研究
- Author:
Detao YIN
;
Zhiwei WANG
;
Hongqiang LI
;
Yongfei WANG
;
Yan ZHANG
;
Jinhua JIANG
;
Qingduan WANG
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
Fragile histidine triad gene;
RT-PCR;
Gene loss
- From:
Journal of Endocrine Surgery
2014;8(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study fragile histidine triad gene(FHIT) gene mRNA expression in 60 samples of papillary thyroid carcinoma(PTC) and matched adjacent non-concerous tissues (NCE),and to explore the role of FHIT gene in the development in PTC.Methods Reverse transcription polymerase chain reaction(RT-PCR) was used to detect FHIT gene mRNA expression in 60 samples of PTC and matched NCE.Results In PTC tissues,the positive rate of FHIT gene mRNA expression was 45.0％ (27/60),lower than that in NCE tissues (100.0％,60/60).FHIT gene mRNA expression was correlated with pathology stage,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion FHIT loss and transcript abnormality might play important roles in proliferation and metastasis of PTC,and might be a useful marker for evaluating the biological behavior of PTC.
