Establishment of Quality Standard for Zhike Qutan Oral liquid
- VernacularTitle:止咳祛痰口服液质量标准的建立
- Author:
Rong QU
;
Yajing QIU
;
Xuequn QIAN
;
Ganggang BAI
;
Xiaopeng CHEN
;
Hui YE
- Keywords:
Zhike Qutan oral liquid;
Platycodonis Radix;
Glycyrrhizae Radix et Rhizoma;
Belamcandin;
Quality standard;
TLC;
HPLC
- From:
China Pharmacist
2017;20(8):1511-1513
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish the quality standard for Zhike Qutan oral liquid.Methods: A TLC method was used for the qualitative identification of Platycodonis Radix and Glycyrrhizae Radix et Rhizoma;the content of belamcandin in Belamcandae Rhizoma was determined by an HPLC method on a Waters Symmetry C 18 column(150 mm× 4.6 mm , 3.5 μm)with the mobile phase consisting of acetonitrile-water (14∶86), the flow rate was 1.0 ml·min-1 , the column temperature was 35℃ and the detection wavelength was 265 nm.Results: The TLC spots were clear without interference from the negative control.The linear range of belamcandin was 0.115-2.880 μg (r=0.999 9),and the average recovery was 92.44% (RSD=1.83% , n =6).Conclusion: The method is simple and rapid with good reproducibility, which can be used for the quality control of Zhike Qutan oral liquid.
