Amniotic fluid chromosome detection for 95 NIPT high-risk pregnant women
10.3969/j.issn.1673-4130.2017.13.008
- VernacularTitle:95例NIPT高风险者羊水染色体检测结果分析
- Author:
Huijuan LAN
;
Congwen SHAO
;
Huilin WANG
;
Zehao YAN
;
Shuping XIE
;
Likuan XIONG
- Keywords:
prenatal diagnosis;
amniotic cavity puncture;
noninvasive prenatal testing
- From:
International Journal of Laboratory Medicine
2017;38(13):1749-1750,1753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis of the detection result of amniotic fluid chromosome which in NIPT high-risk pregnant women.Methods Amniotic fluid cells via amniotic cavity puncture were cultured and analyzed,the chromosome karyotypes were observed.Results The highest positive predictive value of NIPT was for trisomy 21(85.00%),then trisomy 18(75.00%),sex chromosome abnormalities(68.00%),other chromosome abnormalities(41.67%),trisomy 13 (25.00%).Conclusion The highest accuracy of NIPT was shown in detection of Down''s syndrome by NIPT.NIPT was screening test which is effective and noninvasive in prenatal diagnosis.Amniotic fluid Chromosomal karyotype analysis was the gold standard in the diagnosis of fetal chromosomal disease.
