Ionization interference and its suppressing in determination of heavy metal elements in iron dextran by inductively coupled plasma optical emission spectrometry
10.7501/j.issn.1674-6376.2017.04.013
- VernacularTitle:电感耦合等离子体发射光谱法测定右旋糖酐铁重金属元素中的电离干扰及抑制方法
- Author:
Chao MA
;
Nan MI
;
Simeng FANG
;
Kexin ZANG
;
Mujun SU
- Keywords:
inductively coupled plasma optical emission spectrometry (ICP-OES);
ionization interference;
iron dextran
- From:
Drug Evaluation Research
2017;40(4):506-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for the determination of eight heavy metal elements ofPb,Cd,As,Hg,Co,V,Se,Mo in iron dextran by inductively coupled plasma optical emission spectrometry (ICP-OES).Method Through selection of detection wavelengths,optimization of instrument parameters,correction of spectral interference,verification of ionization interference and investigation of suppression methods,the eight heavy metal elements were analyzed by ICP-OES.Results The recovery rate of the detected elements increased 5％ to 10％ by suppression of ionization interference.The accuracy of the method was good.The spiked recovery rates of the detected elements were from 95.7％ to 101.1％.The precision of the method were good (RSD ＜ 3.6％,n =6).The linearities of the detected elements were good,and the correlation coefficients were all greater than 0.999.The detection limits were from 0.15 to 8.09 ng/mL.The quantization limits were from 0.46 to 24.26 ng/mL.Conclusion The method was accurate,sensitivity,rapid and reliable,which can be applied to the determination of contents of eight heavy metal elements in iron dextran.
