Research advances in subventricular zone irradiation in glioblastoma
10.3760/cma.j.issn.1004-4221.2017.06.022
- VernacularTitle:胶质母细胞瘤室管膜下区(SVZ)放疗研究进展
- Author:
Chengang WANG
;
Yijun LUO
;
Minghuan LI
;
Jinming YU
- Keywords:
Glioblastoma multiforme;
Subventricular zone;
Glioma stem cells;
Radiotherapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2017;26(6):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma multiforme (GBM,WHO grade IV) contains some glioma stem cells which have unique self-renewal capacity and multilineage potency.There are numerous neural stem cells in the subventricular zone (SVZ) of adult human brain;it may also act as a storehouse of glioma stem cells that can promote the development and recurrence of a tumor.GBM involving SVZ is prone to early recurrence and intracranial metastasis after resection,so irradiation of the SVZ potentially influences the survival of GBM patients.This review provides a summary of related experimental and clinical studies,and discusses the value of irradiation of the SVZ in GBM patients and the direction of future research.
