Research progress of microRNA 222 in cardiovascular disease
10.3969/j.issn.1006-6187.2017.06.018
- VernacularTitle:microRNA222在心血管疾病中的研究进展
- Author:
Yanyan LIN
;
Linshuang ZHAO
- Keywords:
microRNAs;
microRNA222;
Cardiovascular diseases
- From:
Chinese Journal of Diabetes
2017;25(6):565-568
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a class of endogenous;non-coding small RNA molecules;which can degradate target mRNA;or negatively regulate the expression of the corresponding target genes in the post transcriptional level through inhibiting target gene translation;inducing degradation and so on.MiRNAs exert important parts in the process of metabolism;cell growth;and development.MicroRNA 222 (miR-222) is an important member of microRNAs;which plays an important role in cell proliferation;differentiation;apoptosis and the development of a variety of biological tissues.Recent studies found that miR-222 could mediate a variety of physiological and pathological processes;and significantly influence the development of cardiovascular disease.MiR-222 has an important role in inflammatory response and apoptosis.Here;we reviewed the relationship between miR-222 and cardiovascular disease.
