Efficacy of Lianhua Dingchuan Tablets in bronchial asthma
10.3969/j.issn.1672-8467.2017.03.013
- VernacularTitle:连花定喘片治疗支气管哮喘的疗效
- Author:
Chen BAO
;
Xia ZHOU
;
Nana FENG
;
Jing LI
;
Yuanlin SONG
;
Chunxue BAI
;
Dong YANG
;
Jian ZHOU
- Keywords:
Lianhua Dingchuan Tablets;
bronchial asthma;
airway hyperresponsiveness;
cytokines;
dexamethasone
- From:
Fudan University Journal of Medical Sciences
2017;44(3):333-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of Lianhua Dingchuan Tablets in bronchial asthma.Methods Fifty BALB/C mice were randomly and equally divided into control (Con) group,ovalbumin (OVA) group,dexamethasone (DEX) group,high-dose Lianhua group,low-dose Lianhua group.The mice were sensitized and challenged with OVA plus aluminium hydroxide to establish asthmatic model and were pre-treated 30 minutes before challenge.Specific airway resistance (sRaw) was used to evaluate airway hyperresponsiveness,and airway inflammatory changes were measured.ELISA and Magnetic Luminex(R) were used to quantified the levels of IL-4,IL-13 and INF-γ.Results Airway resistance significantly decreased in DEX group and High-dose Lianhua group (P＜0.05).Levels of inflammatory cells and IL-13 in BALF evidently reduced in DEX group,high-dose Lianhua group and low-dose Lianhua group (P ＜ 0.05),while IL-13 level in serum only decreased in DEX group.There was no significant changes in the levels of IL 4 and INF γ among those groups.Conclusions Lianhua Dingchuan Tablets might relieve the symptoms of asthma by reducing IL-13 level and inhibiting the airway inflammation.
