Role and mechanism of thrombin in white matter injury after intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2017.05.012
- VernacularTitle:凝血酶在脑出血后白质损伤中的作用及其机制
- Author:
Qiuyue ZHENG
;
Yingzhu CHEN
- Keywords:
Cerebral Hemorrhage;
Thrombin;
White Matter
- From:
International Journal of Cerebrovascular Diseases
2017;25(5):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Intracerebral hemorrhage accounts for about 10%-30% of all stroke types.It is characterized by rapid onset, rapid progress, varied clinical symptoms, high morbidity and mortality, and poor prognosis.After the intracerebral hemorrhage, various inflammatory mediators result in white matter lesions and cognitive impairment.Thrombin acting on thrombin receptors at low concentration induces neuroprotection and at high concentration causes brain injury.This article reviews the role and mechanism of thrombin in white matter injury after intracerebral hemorrhage.
