Angiopep-2 conjugated brain targeting system:research advances

VernacularTitle:angiopep-2修饰的脑靶向制剂研究进展
Author: Rong SUN ; Qiuying CHEN ; Zhennan LIU ; Qihai ZHANG ; Yihua YANG
Keywords: brain-blood barrier(BBB); angiopep-2; brain targeting
From: Journal of International Pharmaceutical Research 2017;44(6):510-513
CountryChina
Language:Chinese
Abstract: The key factor of chemotherapy for brain disorders is to penetrate brain blood barrier(BBB). Receptor mediated en-docytosis is one of the mechanisms for drug carriers to cross the BBB. Angiopep-2(ANG)can specifically bind to low density lipopro-tein receptor-related proteins 1(LRP-1)overexpressed on BBB and glioma cells,thus exhibits a higher LRP-mediated BBB penetra-tion capability. Its targeting efficiency is higher than that of other targeting molecules such as transferrin and(TF)lactoferrin(LF). This paper introduces the structure and function of ANG,and its application in brain targeting delivery systems,in order to provide references for research and development of brain targeting preparations and guidance for therapy of brain diseases.