Chemotherapy resistance of 5-fluorouracil:research advances
10.13220/j.cnki.jipr.2017.06.004
- VernacularTitle:5-氟尿嘧啶化疗耐药的研究进展
- Author:
Xin DING
;
Guojiang CHEN
- Keywords:
5-fluorouracil;
chemotherapy resistance;
thymidylate synthase
- From:
Journal of International Pharmaceutical Research
2017;44(6):491-494
- CountryChina
- Language:Chinese
-
Abstract:
5-Fluorouracil(5-FU)has been widely used to treat gastrointestinal,head,neck,chest and ovarian malignant tu-mors since 1957. As an analogue of pyrimidine,5-FU plays anti-cancer roles by inhibiting thymioylate synthase and integrating its me-tabolites into DNA and RNA. Although 5-FU is one of the first-line therapeutic compounds for gastrointestinal malignant tumor as a sin-gle drug or in combination with other drugs,its effectiveness is hindered by its low efficiency,which may be due to chemotherapy re-sistance. 5-FU chemotherapy resistance may stem from enzyme abnormality,genetic abnormality and tumor microenvironment. In this paper,we make a review about 5-FU actions and the mechanisms underlying chemotherapy resistance.
