Expression of serum anti-IMP1 autoantibody IgG in patients with hepatocellular carcinoma and itsrelationship with clinicopathological parameters
10.3969/j.issn.1673-4130.2017.09.005
- VernacularTitle:抗IMP1自身抗体IgG在肝癌患者血清中的表达及其与临床病理参数的关系
- Author:
Ruiyang RUAN
;
Xiurong CHEN
;
Shiyuan ZHAO
- Keywords:
liver cancer;
IMP1;
autoantibody;
IgG;
metastasis
- From:
International Journal of Laboratory Medicine
2017;38(9):1165-1166,1171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum anti-insulin-like growth factor-Ⅱ mRNA binding protein1(IMP1) autoantibody IgG expression in hepatocellular carcinoma(HCC) patient and its relationship with clinicopathological parameters.Methods ELISA method was used to detect serum anti-IMP1 autoantibody IgG in 120 cases of HCC,then the detection results were compared those in 115 healthy individuals(control group).The relationship between serum anti-IMP1 autoantibody IgG level with clinicopathological parameters in HCC patients was analyzed.Results The serum anti-IMP1 autoantibody IgG levels in the HCC group and control group were(1.512±0.685),(1.080±0.301)μg/mL respectively,the HCC group was significantly higher than the control group with statistical difference(P<0.001);serum anti-IMP1 autoantibody IgG in HCC patients was related with the tumor size,tumor differentiation degree,TNM grade and intrahepatic metastasis(P<0.001),and had no obvious relation with the age,sex,drinking and HBV infection(P>0.05).Conclusion Serum anti-IMP1 autoantibody IgG expression increased is increased in HCC patient.The detection of serum anti-IgG autoantibody IMP1 level in HCC is conducive to judge the malignancy degree of HCC.
