Application value of lipopolysaccharides and (1-3)-β-D glucan detection in acute pancreatitis complicating infection
10.3969/j.issn.1673-4130.2017.09.004
- VernacularTitle:血浆内毒素及(1-3)-β-D葡聚糖测定在急性胰腺炎感染中的应用价值
- Author:
Yuejuan SONG
;
Qiangsheng FENG
;
Xiaoqing HA
- Keywords:
acute pancreatitis;
endotoxin;
(1-3)-β-D glucan
- From:
International Journal of Laboratory Medicine
2017;38(9):1163-1164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application value of endotoxin and (1-3)-β-D glucan detection in the patients with acute pancreatitis(AP).Methods The MB-80 microbiology rapid dynamic detection system was applied to detect the concentration of plasma LPS and (1-3)-β-D glucan in the patients with AP.Then the results were analyzed.Results Among 184 cases of AP complicating peripancreatic abscess and bilateral lung infection,endotoxin G-lipopolysaccharides positive was in 23 cases,the average value was 394.07 pg/mL,the positive rate was 10.87%,and 15 cases of Gram-negative bacterial infection were verified by the microorganism culture.Among 175 cases of AP complicating peripancreatic abscess and bilateral lung infection,67 cases were(1-3)-β-D glucan positive,the average value was 93.22 pg/mL,the positive rate was 38.29%,which were with the positive rate of serum(1-3)-β-D glucan in the non-AP group,the difference was statistically significant(P<0.05),the microorganism culture or smear verified that 22 cases were fungal infection.Conclusion Plasma endotoxin and (1-3)-β-D glucan detection provides the laboratory biological indicator and is conducive to the assessment of AP infection severity and clinical medication.
