Advances of polypeptide fragment of rabiesvirus glycoprotein as a brain-targeting carrier
10.3969/j.issn.1001-1978.2017.05.004
- VernacularTitle:狂犬病毒糖蛋白中多肽片段作为脑靶向药物载体的研究进展
- Author:
Ligang CHEN
;
Jing WU
;
Peng LUO
;
Ailing FU
- Keywords:
RVG peptide;
blood-brain barrier;
brain targeting;
polymer;
nanoparticle;
protein;
nucleic acid
- From:
Chinese Pharmacological Bulletin
2017;33(5):607-611
- CountryChina
- Language:Chinese
-
Abstract:
Polypeptide fragment of rabies virus glycoprotein(RVG)has become one of the most popular polypeptides in drug delivery field,because of its advantages of neurotropiam,penetration of blood-brain barrier and biosafety.Polypeptide fragment of RVG can directly deliver proteins and nucleic acids into brain.Additionally,when polypeptide fragment of RVG couples with drug-loading polymers,nanoparticles or liposomes,it can mediate the latters into brain.The application of the RVG polypeptide fragment provides a safe and effective approach for the treatment of brain diseases with biomolecules,such as chemicals,proteins.plasmids,siRNA,miRNA.
