Curative Effect of Moxifloxacin Solution Atomization Inhalation in Treatment COPD Combined with Reslpiratory Failure
10.13241/j.cnki.pmb.2017.23.040
- VernacularTitle:莫西沙星溶液雾化吸入治疗COPD合并呼吸衰竭的疗效
- Author:
Zongmin SHI
;
Yongzhen YANG
;
Guofang YIN
;
Yuanmei ZHANG
;
Deyu LUO
- Keywords:
Chronic pulmonary obstructive pulmonary disease;
Respiratory failure;
Moxifloxacin solution;
Atomization inhalation;
Curative effect
- From:
Progress in Modern Biomedicine
2017;17(23):4568-4571
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the curative effect of moxifloxacin solution atomization inhalation in the treatment of chronic obstructive pulmonary disease (COPD) combined with respiratory failure.Methods:94 cases of COPD patients combined with respiratory failure from May 2014 to May 2016 were selected and divided into the control group(n=47) and the research group (n=47) acording to the lottery method,the control group received routine treatment,while the research group was treated based on the control group with moxifloxacin solution inhalation treatment.The curative effect,serum tumor necrosis factor-α(TNF-α),c-reactive protein (CRP) and interleukin 10 (IL-10),creatine phosphokinase (CK),aspertate aminotransferase (AST) levels,the blood oxygen partial pressure (PaO2),CO2 partial pressure (PaCO2),APACHE Ⅱ score and occurrence of adverse reactions were compared between two groups.Results:After treatment,the total effective rate of research group was higher than that of the control group (P＜0.05).The serum levels of TNF alpha,CRP,PaCO2,CK,AST,APACHE Ⅱ score of research group were evidently lower than those of the control group (P＜0.05).The serum levels ofIL-10,PaO2 of research group were evident higher than those of the control group (P＜0.05).The occurrence of adverse reactions showed no differences between the two groups (P＞0.05).Conclusion:Moxifloxacin solution atomization inhalation was effective in the treatment of COPD combined with respiratory failure,which might be related to the inhibition of inflammatory response,and improvment of breath.
