Research advances in adult hepatic progenitor cells
10.3969/j.issn.1001-5256.2017.05.043
- VernacularTitle:成体肝祖细胞的研究进展
- Author:
Fei LI
;
Zhenzeng MA
;
Lungen LU
- Keywords:
hepatic progenitor cells;
liver regeneration;
carcinoma,hepatocellular;
stem cell transplantation;
review
- From:
Journal of Clinical Hepatology
2017;33(5):994-997
- CountryChina
- Language:Chinese
-
Abstract:
The liver has a strong regenerative capacity,and in case of acute injury,the proliferation of mature hepatocytes helps to complete liver regeneration.However,in case of chronic injury,the proliferative capacity of mature hepatocytes is damaged or exhausted,and the activation,proliferation,and differentiation of hepatic progenitor cells are involved in liver regeneration.This article summarizes the characteristics and origins of hepatic progenitor cells,their role in tissue repair after liver injury and development of liver cancer,and potentials and problems of cell transplantation in the treatment of liver diseases.It is pointed out that an understanding of the biological characteristics of hepatic progenitor cells,their role in liver injury and liver cancer,and related pathogenesis helps with the treatment of liver diseases.
