Research on Main Effective Chinese Materia Medica inQuban Prescription for Intervention in Melanin Synthesis
10.3969/j.issn.1005-5304.2017.07.020
- VernacularTitle:祛斑中药组方干预黑素合成的主效应中药剖析
- Author:
Zhichun CHEN
;
Yinghao WANG
;
Liping ZHANG
;
Mingjin LAN
- Keywords:
factorial design;
tyrosinase;
melanin;
Quban Prescription;
effective Chinese materia medica
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2017;24(7):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the major effective Chinese materia medica inQuban Prescription for intervention in melanin synthesis.Methods 3×2 factorial design was used. The factors of investigation were Crataegi Fructus, Angelicae Sinensis Radix and Corni Fructus. Tyrosinase activity, melanin generation and auto-oxidation of dopa were determinated respectively; and the major effective Chinese materia medica ofQuban Prescription for intervention in melanin synthesis was analyzed by SPSS16.0 software.Results Tyrosinase activity was remarkably inhibited by Corni Fructus (P<0.05). Melanin generation was remarkably inhibited by Corni Fructus and Angelicae Sinensis Radix (P<0.01). Auto-oxidation of dopa was remarkably inhibited by Corni Fructus and Angelicae Sinensis Radix (P<0.05). Corni Fructus was in an absolute leading position.ConclusionCorni Fructus is the major effective Chinese materia medica in inhibiting tyrosinase activity, melanin generation and auto-oxidation of dopa in the prescription.
