Extended adjuvant temozolomide for treatment of glioblastoma multiforme:experience of a single institu- tion
10.3969/j.issn.1006-5725.2017.16.035
- VernacularTitle:长周期替莫唑胺治疗胶质母细胞瘤
- Author:
Changguo SHAN
;
Mingyao LAI
;
Weiping HONG
;
Junjie ZHEN
;
Qingjun HU
;
Xuebing LING
;
Linbo CAI
- Keywords:
Glioblastoma;
temozolomide;
extended adjuvant therapy
- From:
The Journal of Practical Medicine
2017;33(16):2743-2746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the impact of additional cycles of temozolomide on the survival of glio-blastoma(GBM)patients after 6 months of maintenance temozolomide(TMZ)following concurrent TMZ chemo-therapy and radiation therapy. Methods Data of 51 GBM patients from 2009 to 2015 were retrospectively studied and the therapeutic effect was assessed according to whether receiving long-term treatment with TMZ. Results Sev-enteen of fifty-one GBM patients received 8 or more cycles and prolonged treatment improved progression-free sur-vival(P=0.011)and overall survival(P=0.004). Conclusions Extended use of TMZ is safe to GBM patients , which may improve response OS and PFS compared to conventional regimen. Prospective studies in larger popula-tions are needed to better-define the population to whom it can be proposed and its optimal duration.
