Application of HbA1C for diagnosing diabetes in Harbin
10.3760/cma.j.issn.1000-6699.2017.07.005
- VernacularTitle:哈尔滨地区HbA1C用于糖尿病的诊断
- Author:
Haiqiao YU
;
Weilun CHENG
;
Xincai HONG
;
Yuru JIA
;
Siying LIU
;
Wei QUAN
;
Weiwei SHANG
;
Yue ZHOU
;
Jian LI
;
Shuang YAN
- Keywords:
HbA1C;
Diabetes;
Diagnosing;
Cutoff point
- From:
Chinese Journal of Endocrinology and Metabolism
2017;33(7):562-566
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the sensitivity and specificity of different HbA1C cutoff points for diabetes diagnosis in high risk outpatients in Harbin.Methods A total of 2 122 high risk outpatients(male 1 032 and female 1 090)for diabetes screening in the Fourth affiliated Hospital of Harbin Medical University from April 2013 to February 2015 were included in this study, with the average age of(49.26±13.00)year. Oral glucose tolerance tests(OGTT)were conducted and HbA1C levels were examined in these patients. The sensitivity and specificity of different HbA1C cutoff points were calculated and a receiver operator characteristic(ROC)curve was then built.Results The average level of HbA1C in these subjects was(6.45±1.72)%. The prevalence of diabetes was 41.85%. The area under ROC curve(AUC)was 0.89 with the optimal cutoff point of HbA1C 6.0% and 0.68 for the highest Yonden index. The sensitivity and specificity of HbA1C 6.0% were 84.01% and 83.67% respectively. The sensitivity and specificity of HbA1C 6.5% were 62.84% and 95.92%, respectively. The AUC of HbA1C≥6.5% was 0.732. Conclusion HbA1C works well as the diagnostic standard for diabetes in high risk outpatients of Harbin city. The cutoff point of HbA1C 6.0% is suitable for screening diabetes in high risk population, and HbA1C 6.5% is appropriate for diabetes diagnosis, with high sensitivity and specificity.
