Role of ceramide in development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2017.08.038
- VernacularTitle:神经酰胺在非酒精性脂肪性肝病发生发展中的作用
- Author:
Haijing HAN
;
Xue QI
;
Chunyan NIU
- Keywords:
fatty liver;
ceramides;
review
- From:
Journal of Clinical Hepatology
2017;33(8):1584-1588
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome caused by liver damage factors except alcohol and has the major feature of diffuse macrovesicular hepatocyte steatosis.Thetwo-hit hypothesis can partly explain the pathogenesis of NAFLD.Recent studies have found that ceramide is a key molecular messenger involved in the development and progression of NAFLD,and as a sphingolipid,it is closely associated with the two-hit hypothesis.This article reviews the role of ceramide in NAFLD.
